• The oxidation of the lipid

  2021-05-24

  

  The oxidation of the lipid fraction of meat is an extremely complex process because of the high sensitivity of oxidation products to decomposition, their reactions with other components, the complex effect of catalysts and the presence of antioxidants. These changes are the main cause of limited she

• Our study found a significant association

  2021-05-22

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P caudatin status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between EGFR mutations

• HCV has evolved mechanisms to

  2021-05-22

  

  HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 Amyloid β-peptide (10-35), amide of the N-terminus of E2, which is referred to

• DHODH activity has been traditionally measured with the stan

  2021-05-22

  

  DHODH activity has been traditionally measured with the standard colorimetric assay that monitors 2,6-dichloroindophenol (DCIP) reduction as absorbance decrease at 600 nm . This assay has permitted the identification of several families of DHODH inhibitors in a successful high-throughput screening (

• The binding of collagen X

  2021-05-22

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• To better understand Wolbachia s dependence on these enzymes

  2021-05-22

  

  To better understand Wolbachia’s dependence on these enzymes, RNAi experiments targeting these transcripts will be required to examine the consequences of their down-regulation on Wolbachia in the different tissues of the parasite. Initial studies have shown that decreases in Bm-cpl-3 and Bm-cpl-6 t

• br Advantages of modified proteins over

  2021-05-22

  

  Advantages of modified proteins over unmodified ones In contrast to small-molecule drugs, proteins are readily amenable to site-specific alterations through genetic engineering. In principle, therefore, it is possible to build in features that allow them to remain active for longer in the body an

• Synthetic peptides have proven highly

  2021-05-21

  

  Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to synthetic collagen-like peptides. First, the thermal stability of

• continue to  br Materials and methods br Results

  2021-05-21

  

  Materials and methods Results Discussion Oxidative stress is a disturbance in the balance of pro- and antioxidant species, resulting in oxidative damage to membrane proteins, lipids, and DNA. Oxidative stress is a predisposing factor for the progression of metabolic diseases and liver injur

• At present there have been relatively few studies that evalu

  2021-05-21

  

  At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal KT203 nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relationships is needed, which m

• br Materials and methods br Results Among probes

  2021-05-21

  

  Materials and methods Results Among 17,061 probes, the ARCA Cy5 EGFP mRNA of 758 probes (4.4%) showed at least a 2-fold upregulation (230 probes) or downregulation (528 probes) at day 3 after VMH lesioning as compared with sham-VMH lesioning. Supplement Table 1 shows the upregulated (>2-fold)

• br Coactivator Binding Sets APC C Catalytic

  2021-05-21

  

  Coactivator Binding Sets APC/C Catalytic Core in Motion A coactivator not only recruits substrates to APC/C [18] (Figure 3B), but also stimulates repositioning of the catalytic core 19, 24. High-resolution cryo-EM maps of apo forms of APC/C without a coactivator show the catalytic core and platfo

• br Methods br Results br Discussion Preclinical

  2021-05-21

  

  Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the pyrazine uses with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not signifi

• The activity of chromenones bearing heteroaryl groups at the

  2021-05-21

  

  The activity of chromenones bearing heteroaryl groups at the 8-position is summarised in . Replacement of the 8-phenyl substituent of by a thiophen-2-yl group ( and ) did not improve DNA-PK inhibitory activity, although the 4-phenylthiophen-2-yl derivative (), together with the bithiophene analogue

• Tumor cells exposed to the effect of

  2021-05-21

  

  Tumor protein kinase exposed to the effect of these compounds were shown to become chemo and radio-sensitive. Based on that, it was possible to anticipate the selectivity requirement for DNA-PK inhibition and the best route for their development. Accordingly, prompted by the clinical significance a

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