• SCR7 Petrat et al could show that even a low

  2022-04-11

  

  Petrat et al. could show, that even a low dosage of 10-mg/kg glycine (133 μmol/kg) has a beneficial effect on the small intestine after I/R. In regard to glycine, β-alanine has a clearly higher EC50 to the GlyR and activates the receptor with an efficiency of only 34.6%.16, 17 Therefore, it can be c

• methoxy The existence of EAAT subtypes raises

  2022-04-11

  

  The existence of 5 EAAT subtypes raises obvious questions as to the cellular and anatomical distribution of the various transporters (for review, see Gegelashvili & Schousboe, 1998, Danbolt, 2001). While difference in techniques (i.e., protein vs. mRNA), reagents, and preparations (i.e., in vivo vs.

• br Ligand binding free energies In

  2022-04-11

  

  Ligand-binding free energies In order to compute the absolute free TMC647055 Choline salt associated with binding a ligand to a flexible iGluR LBD, a theory that accounts for all the principal thermodynamic contributions from ligand docking and LBD closure had to be developed. This was accomplis

• MAPK are involved in a large variety

  2022-04-09

  

  MAPK are involved in a large variety of solid and hematolgical neoplasms and, indeed, several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK1/2, MEK1/2, RAF, RAS, DUSP1 and ERK5 [11], [12]. Among them, alteration of the RAS-RAF-MEK1/2-ER

• Bile acids BAs are critical for

  2022-04-09

  

  Bile acids (BAs) are critical for facilitating the pak1 of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregnane X receptor, and vitamin D recept

• br Acknowledgments br The study

  2022-04-09

  

  Acknowledgments The study was funded by the European Commission FP7-project Beta-JUDO (Grant 279153), and Swedish Diabetes Association (Grant DIA 2013-043) and Family Ernfors Foundation (Grant 150430). Free fatty calmodulin dependent protein kinase receptors (FFARs) represent a family of G-

• PF-04620110 Following these discoveries the term

  2022-04-09

  

  Following these discoveries, the term ferroptosis was coined in 2012 [25], to describe this iron-dependent, non-apoptotic form cell death induced by erastin and RSL3. This discovery was accompanied by the development of the first small molecule ferroptosis inhibitor, termed ferrostatin-1, and the de

• A breakthrough in the understanding of the

  2022-04-09

  

  A breakthrough in the understanding of the unique properties of GPX4-downregulation-induced cell death was accomplished when Seiler et al. in 2008 demonstrated the role of 12/15-lipoxygenase (12/15-LOX), a polyunsaturated fatty Imatinib metabolizing enzyme [92], in the execution of GPX4-knockout-me

• br Application of TIRFM to visualizing exocytosis TIRFM was

  2022-04-09

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Phusion high-fidelity DNA polymerase mg (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such

• The replenishment time course of already tethered vesicle to

  2022-04-09

  

  The replenishment time course of already-tethered vesicle to became release ready, was examined by TIRFM imaging combined with calcium uncaging. By UV-flash photolysis of caged calcium, intracellular calcium concentration raises rapidly and homogenously throughout the cell (Ellis-Davies, 2008). Upon

• Glycine released from astrocytes as well as neurons

  2022-04-09

  

  Glycine released from astrocytes as well as neurons is also known as a co-agonist of NMDAR (Roux and Supplisson, 2000). Neuronal glycine in mouse hippocampus might be released from glutamatergic terminals (Muller et al., 2013) that express functional BOP reagent receptors (Rodriguez et al., 1997).

• The majority of HCV unaware individuals for

  2022-04-08

  

  The majority of HCV-unaware individuals, for which HCV RNA was obtainable, had active HCV infection and overall almost one-fifth of them had advanced liver disease according to the FIB-4 score; these persons can be classified as having a late HCV diagnosis and are in immediate need of HCV treatment

• In our previous studies examining

  2022-04-08

  

  In our previous studies examining erectile responses in sGCα1−/− mice, we found that the sGCα1 subunit was required to obtain proper erectile responses to substances generally known to exert their actions by sGC.17, 18 Based on our previous observation of residual relaxing responsiveness to exogenou

• (±)-Nutlin-3 Considering its role in regulating cytoske

  2022-04-08

  

  Considering its role in regulating cytoskeletal dynamics, the Rho kinase effector ROCK has been particularly implicated in tumor metastasis. The ROCK inhibitors Y27632 and fasudil have been extensively studied in cancer and beneficial effects have been observed in many types of cancers (Kale et al.,

• br Conclusions br Introduction G protein coupled receptors G

  2022-04-08

  

  Conclusions Introduction G protein-coupled receptors (GPRs) share common structural motifs, including seven transmembrane helices, and the ability to activate heterotrimeric G proteins such as Gs, Gi, Gq and G12/13. A variety of GPR cellular functions are mediated by second messengers such as

14876 records 456/992 page Previous Next First page 上5页 456457458459460 下5页 Last page