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The srd a isoforms showed unique expression profiles
2023-09-26

The srd5a isoforms showed unique expression profiles in early FHM development (Fig. 2). Similar to amphibian embryos, there was a high abundance of both srd5a1 and srd5a3 at 1dpf in FHMs, suggesting that mRNA for these enzymes may be maternally deposited and that these enzymes may play a key role in
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The relatively high concentration of
2023-09-26

The relatively high concentration of 5-HT used in this study (100 µM) is consistent with the concentrations used in other published ex vivo studies (Ropert and Guy, 1991, Passani et al., 1994, Shen and Andrade, 1998). In our paradigm 5-HT was focally applied at the surface of the slice via a fast pe
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Maintaining the normal vaginal fluid
2023-09-26

Maintaining the normal vaginal fluid acidity is important for vaginal functions (Wagner and Levin 1984). Estrogen has been shown essential in maintaining the acidity of vaginal fluid, in which its deficiency could cause vaginal fluid pH to increase (Gorodeski et al. 2005). After menopause, low estro
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bcrp transporter Aromatization of the pyrrole ring after ani
2023-09-26

Aromatization of the pyrrole ring after anion capturing, using acceptor atoms with electron deficiency (B & Be), and substitution of strong electron withdrawing groups such as CN were three strategies used to design a new class of anion receptors. Comparison of the anion affinities of these anion re
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Knowledge about adipose tissue has evolved considerably over
2023-09-26

Knowledge about adipose tissue has evolved considerably over the last two decades. Always been described as an inert tissue having the function of stocking lipids, adipose tissue is now recognized as a real organ with both metabolic and endocrine functions secreting various factors into the blood to
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ML-193 br Material and methods br Results br Discussion
2023-09-26

Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential ML-193 for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginase is
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Sulforaphane Furthermore we also found that the basic level
2023-09-26

Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 Sulforaphane than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS observed in mt
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br Application of bamboo in the
2023-09-26

Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat
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br HMGB proteins and chromatin structure The multifaceted
2023-09-26

HMGB proteins and chromatin structure The multifaceted roles played by HMGB (formerly called HMG-1 and -2) proteins in modulating chromatin structure, gene transcriptional activity and cellular phenotype have been covered in a number of recent reviews and readers are referred to these for in-dept
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Introduction Plant pathogenic fungi are major
2023-09-26

Introduction Plant pathogenic fungi are major pathogens in agricultural diseases and the cause of large crop losses worldwide. There are many kinds of plant pathogenic fungi, with various modes of action. For example, Botrytis cinerea (B. cinerea) is the disease pathogen in the economically importa
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What are the in situ effects of
2023-09-26

What are the in-situ effects of multi-site CaM associations with AT1R? Kai et al. showed that synthetic peptides corresponding to residues 125–137 (rat sequence) in SMD2, 217–227 in the N-terminal side of SMD3, and 304–316 in SMD4JM inhibit to various degrees AngII-induced GTPase activity of isolate
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In addition enhanced AT receptor function abnormally increas
2023-09-26

In addition, enhanced AT1 receptor function abnormally increases central and sympathetic activity, contributing to cardiac and renal disease, which in turn alters homeostasis, increases vulnerability to stress, and further injures the brain, and that AT1 receptor blockade ameliorates excessive sympa
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br Experimental section br Introduction Microglia were disco
2023-09-26

Experimental section Introduction Microglia were discovered as a novel cell population in PAC-1 in 1933 by a Spanish physician and histologist Pío del Río-Hortega [1]. In the eye, scientists used Hortega's staining technique to label the microglia in the retinal outer plexiform layer (OPL) in
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Similar to V the temporal neocortex of mammals
2023-09-26

Similar to V1, the temporal neocortex of mammals, including the primary auditory cortex (A1), is densely innervated by 5-HT fibers originating mainly in the dorsal raphe nucleus (Campbell et al., 1987, Harding and Paxinos, 2004, Törk, 1990), and the major AS 101 of 5-HTRs are expressed throughout t
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br Results br Discussion Today enzymes
2023-09-26

Results Discussion Today, enzymes play important roles in various fields. A good assay for enzyme activity is of great value, especially when it has good specificity, sensitivity, reproducibility and economy. ADK is the first identified enzyme in the metabolic pathway of adenosine salvage [15,
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