• As cytosolic acetyl CoA levels

  2024-04-03

  

  As cytosolic acetyl-CoA levels in hepatocytes descend, cellular production and concentration of cholesterol go down, a change that is known to be sensed by the Sterol response element binding protein (SREBP)/Cleavage-Activating Protein system, leading to SREBP escort to the Golgi apparatus, cleavage

• shows the complexes resulting from interaction of the propos

  2024-04-03

  

  shows the complexes resulting from interaction of the proposed anion receptors with the anions F, Cl, NO, and SO. No imaginary frequency was observed for the optimized complexes indicating the complexes are in potential minima and they are not transition state structures. summarizes the calculate

• br Conclusions In summary aromatase mRNA

  2024-04-03

  

  Conclusions In summary, aromatase mRNA expression in the apexbio dilution of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain of A

• Although the interactions of PhLP

  2024-04-03

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls NS 1619 signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacting partners in

• br Prostate cancer and resistance to AR targeting

  2024-04-03

  

  Prostate cancer and resistance to AR targeting treatment The AR plays a pivotal role in the development, differentiation, homeostasis and secretory function of the normal prostate (Wilson, 2011). The AR is also a key player in many phases of prostate carcinogenesis (Huggins et al., 1941, Scher an

• br Results br Discussion Using primarily

  2024-04-03

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• br Conflicts of interest br Acknowledgements This

  2024-04-02

  

  Conflicts of interest Acknowledgements This work was sponsored by grants from Longyan University Scientific Research Fund for the Young Scholars (LQ2016010), Middle-aged and Young Teachers Education Research Projects of Fujian Province (JAT170569), Longyan University Scientific Research Fund f

• br Concluding Remarks and Future Perspectives

  2024-04-02

  

  Concluding Remarks and Future Perspectives Disclaimer Statement Introduction Aldehyde dehydrogenase ALDHs (E.C. 1.2.1.3) are multigene family of NAD(P)+-dependents group of structurally and functionally related ubiquitously distributed enzymes involved in the specific and irreversible oxida

• The cavity volume of the

  2024-04-02

  

  The cavity volume of the binding pocket may differ not only between species but also among various AhR/ARNT isoforms within a single species. It is noteworthy that even a single amino oicr receptor substitution within a binding pocket may result in a change in the cavity volume. This, in turn, may

• Benzoquinonium dibromide AMPK is an essential player in adip

  2024-04-02

  

  AMPK is an essential player in adiponectin signaling pathway that regulates energy metabolism. The fact that suppression of AMPK activity by compound C largely diminished candesartan-mediated inhibition of NFκB via blocking AT1 also suggests that the AT1-mediated effect is at least partly resulted f

• APPL was the first adaptor protein identified that

  2024-04-02

  

  APPL1 was the first adaptor protein identified that interacts directly with adiponectin receptors [18]. A two-hybrid study by Dong and colleagues revealed that the C-terminal extracellular domain of AdipoR1 interacts with adiponectin, whereas the N-terminal cytoplasmic domain of AdipoR1 interacts wi

• The relatively high concentration of HT used

  2024-04-02

  

  The relatively high concentration of 5-HT used in this study (100 µM) is consistent with the concentrations used in other published ex vivo studies (Ropert and Guy, 1991, Passani et al., 1994, Shen and Andrade, 1998). In our paradigm 5-HT was focally applied at the surface of the slice via a fast pe

• br Adenosine receptors and the adaptive immunity T lymphocyt

  2024-04-02

  

  Adenosine receptors and the adaptive immunity T lymphocytes are responsible for the cell-mediated immune response [95]. These cells can be stimulated by the presentation of antigenic moieties by APCs, such as dendritic cells or macrophages [96]. The presentation of antigenic molecules on the APC

• Patients with ADA SCID may

  2024-04-02

  

  Patients with ADA-SCID may experience autoimmune AEs after SCT (and/or during ERT) that are thought to be related to immune dysregulation prior to achieving complete immune reconstitution. The more common autoimmune manifestations include hemolytic anemia, hypothyroidism, and immune thrombocytopeni

• Our initial approach to identify hits was

  2024-04-02

  

  Our initial approach to identify hits was two-pronged and included a high-throughput screening (HTS) campaign of the OSI cytochalasin d library as well as a virtual screening (VS) campaign, utilizing a publically available crystal structure of ACK1 (PDB code: ). A tolerance for protein flexibility

15281 records 178/1019 page Previous Next First page 上5页 176177178179180 下5页 Last page