• Triptolide: Unveiling Novel Regulatory Functions in Immun...

  2025-09-29

  Explore the unique roles of Triptolide as a potent IL-2/MMP inhibitor and regulator of pluripotency, with emphasis on novel immune and epigenetic mechanisms. This in-depth article highlights Triptolide's applications in advanced cancer and developmental biology research, offering insights distinct from prior reviews.

• Erastin: A Breakthrough Ferroptosis Inducer for Advanced ...

  2025-09-28

  Explore the scientific foundations and cutting-edge applications of Erastin as a ferroptosis inducer in cancer biology research. Discover how Erastin enables targeted oxidative stress assays and novel approaches to cancer therapy, particularly in tumor cells with KRAS or BRAF mutations.

• Sulfo-Cy3 Azide: Enabling Precision Birth Dating and Line...

  2025-09-27

  Explore how Sulfo-Cy3 azide, a sulfonated hydrophilic fluorescent dye, revolutionizes Click Chemistry fluorescent labeling for advanced neurodevelopmental lineage tracing. Learn how its unique properties enable high-resolution, photostable labeling of alkyne-modified oligonucleotides and proteins in aqueous systems, supporting cutting-edge research in developmental neuroscience.

• DRB (5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole): Unve...

  2025-09-26

  Discover how 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) redefines transcriptional elongation inhibition and epigenetic modulation in HIV and cell fate research. This article uniquely explores DRB’s mechanistic intersection with m6A-driven phase separation, opening new avenues in antiviral and stem cell biology.

• Bortezomib (PS-341): Illuminating Proteasome Inhibition a...

  2025-09-25

  Explore the multifaceted role of Bortezomib (PS-341) as a reversible proteasome inhibitor in cancer research. This in-depth analysis uniquely integrates 20S proteasome inhibition with the latest insights on pyrimidine salvage regulation, uncovering new avenues for therapeutic intervention.

• Vorinostat (SAHA): Advanced Insights into HDAC Inhibition...

  2025-09-24

  Discover how Vorinostat, a potent histone deacetylase inhibitor, uniquely orchestrates mitochondrial apoptosis through epigenetic modulation in oncology. This article explores recent mechanistic advances and unveils novel intersections with RNA Pol II–driven cell death pathways.

• Plerixafor (AMD3100): A Versatile CXCR4 Antagonist in Can...

  2025-09-23

  Explore the multifaceted applications of Plerixafor (AMD3100), a potent CXCR4 chemokine receptor antagonist, in cancer metastasis inhibition and hematopoietic stem cell mobilization. This article delves into mechanistic insights, comparative inhibitor data, and emerging directions in CXCL12-mediated chemotaxis research.

• br Discussion AhR is a receptor

  2025-03-03

  

  Discussion AhR is a receptor that binds to a great variety of lipophilic compounds, in particular those containing at least one aromatic ring (Abel and Haarmann-Stemmann, 2010, Guyot et al., 2013, Hahn, 2002). The main known function of this receptor is to induce the metabolism of these compounds

• In our study the expression levels of adiponectin and

  2025-03-03

  

  In our study, the expression levels of adiponectin and its receptors in the uteri, conceptuses, and throphoblasts were determined by the stage of early pregnancy. Therefore, it could be hypothesized that the adiponectin system is regulated by the local hormonal milieu. Hormonal regulation in the ute

• The subdivision of HT receptors started in the

  2025-03-03

  

  The subdivision of 5-HT receptors started in the 1950s by Gaddum and colleagues, when they realised that in the guinea pig ileum, the effects of 5-HT could be blocked in part by morphine (M), and in part by dibenzyline (D). Gaddum and Picarelli proposed two receptor classes, 5-HT M and 5-HT D (1957)

• Valinomycin We also demonstrate that PACAP treatment dose de

  2025-03-03

  

  We also demonstrate that PACAP treatment dose-dependently disrupts performance in the 5CSRTT, suggestive of attentional deficits, another core feature of mood and anxiety disorders. Treatment with PACAP (.5–1.0 µg) decreased the percentage of correct responses, increased the percentage of trials in

• br Discussion Myopathic EMG changes

  2025-03-03

  

  Discussion Myopathic EMG changes are frequently detected in patients with MuSK MG, unlike in AChR MG patients [10]. However, these EMG changes are not always accompanied by myopathic histopathological findings. It has been shown that mitochondrial abnormalities seem to be more prominent in MuSK M

• PF 4800567 hydrochloride sale As described in the introducto

  2025-03-03

  

  As described in the introductory section, the rotifer nervous system would be capable to transmit PF 4800567 hydrochloride sale in throughout its neural pathways. In addition, Clément and Amsellem (1989) and Kotikova et al. (2001) suggested acetylcholine to be important for the functioning of rotif

• An alternative to the agonist or antagonist potential in

  2025-03-03

  

  An alternative to the agonist or antagonist potential in drug discovery is the positive allosteric modulator (PAM) approach, which can augment the normal processes of neurotransmission as opposed to directly replacing or antagonizing them. PAMs are thought to bind to sites that are distinct from the

• br Acknowledgements br Introduction Resistant hypertension R

  2025-03-03

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four BEC or more of antihypertensives are also considered resistant (Calhoun

15244 records 4/1017 page Previous Next 12345 下5页 Last page